This index provides a clean navigation layer for the genes section of NeuroWiki. It currently lists 3850 published genes pages and is regenerated from live Wiki.js metadata to avoid recursive markdown-link corruption.
Total: 3850 pages
| Gene | Function | Therapeutic Target |
|---|---|---|
| APP | Amyloid precursor protein | Aβ immunotherapy, BACE inhibitors |
| APOE | Lipid transport, amyloid clearance | Gene therapy, peptide mimetics |
| PSEN1 | Gamma-secretase component | Gamma-secretase modulators |
| PSEN2 | Gamma-secretase component | Gamma-secretase modulators |
| TREM2 | Microglial activation | Agonist antibodies |
| MAPT | Tau protein | Tau immunotherapy, kinase inhibitors |
| BIN1 | Bridging integrator 1 | Not yet targeted |
| CLU (Clusterin) | Amyloid clearance | Not yet targeted |
| ABCA7 | Lipid transport | Not yet targeted |
| SORL1 | APP trafficking | Not yet targeted |
| CD33 | Immune receptor | Anti-CD33 antibodies |
| MS4A | Membrane sphingolipid | Not yet targeted |
| INPP5D | Signaling molecule | Not yet targeted |
| PLD3 | Lysosomal function | Not yet targeted |
| Gene | Function | Therapeutic Target |
|---|---|---|
| SNCA | Alpha-synuclein | Immunotherapy, gene therapy |
| LRRK2 | Leucine-rich repeat kinase | Kinase inhibitors |
| GBA | Glucocerebrosidase | Enzyme enhancement, gene therapy |
| PARK2 (Parkin) | Mitophagy | Not yet targeted |
| PINK1 | Mitophagy | Not yet targeted |
| DJ-1 | Oxidative stress | Not yet targeted |
| VPS35 | Endosomal trafficking | Not yet targeted |
| ATP13A2 | Lysosomal function | Not yet targeted |
| DNAJC13 | Endosomal trafficking | Not yet targeted |
| UCHL1 | Ubiquitin metabolism | Not yet targeted |
| GIGYF2 | IGF signaling | Not yet targeted |
| LRRK2 G2019S | LRRK2 variant | Kinase inhibitors |
| Gene | Function | Therapeutic Target |
|---|---|---|
| C9orf72 | RNA metabolism | ASO, gene therapy |
| SOD1 | Superoxide dismutase | ASO, gene therapy |
| TARDBP (TDP-43) | RNA binding | Not yet targeted |
| FUS | RNA metabolism | Not yet targeted |
| ANG (Angiogenin) | Stress response | Not yet targeted |
| UBQLN2 | Protein degradation | Not yet targeted |
| OPTN | Autophagy | Not yet targeted |
| TBK1 | Autophagy/inflammation | Not yet targeted |
| VCP | Protein degradation | Not yet targeted |
| HNRNPA1 | RNA metabolism | Not yet targeted |
| ATXN2 | RNA metabolism | ASO |
| Gene | Function | Therapeutic Target |
|---|---|---|
| HTT (Huntingtin) | Protein function | ASO, gene therapy |
| HAP40 (HAP40) | Huntingtin interaction | Not yet targeted |
| REST | Transcription factor | Not yet targeted |
See also: Gene Rankings for detailed therapeutic target validation scores.
The following disease-relevant genes are important for neurodegenerative disease research but may have limited or missing wiki coverage:
| Category | Genes | Status |
|---|---|---|
| ALS genes | TUBA4A, TBK1, OPTN, VCP, UBQLN2 | Needs expansion |
| FTD genes | GRN, MAPT, C9orf72, TARDBP, FUS | Needs expansion |
| PD risk genes | GBA1, LRRK2, SNCA, PARK2, PARK7, PINK1, TMEM175, GCH1 | Good coverage |
| AD genes | APP, PSEN1, PSEN2, APOE, TREM2, CLU, PICALM, BIN1 | Good coverage |
| CBS/PSP genes | MAPT, PSAP, CRHR1 | Needs expansion |
| HD genes | HTT, JPH3, TBP | Needs expansion |