| JAG1 — Jagged 1 | |
|---|---|
| Symbol | JAG1 |
| Full Name | Jagged 1 (Notch Ligand) |
| Chromosome | 20p12.2 |
| NCBI Gene | 1950 |
| Ensembl | ENSG00000101384 |
| OMIM | 184756 |
| UniProt | P78504 |
| Diseases | Alzheimer's Disease, Alagille Syndrome, Deafness |
| Expression | Cerebral cortex, Cochlea, Liver, Heart |
Jag1 — Jagged 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
JAG1 encodes the Jagged 1 protein, a member of the Notch family of ligands. Jagged 1 is a transmembrane protein that activates Notch receptors and plays crucial roles in cell fate determination, embryonic development, and tissue homeostasis.
JAG1 is a DSL (Delta-Serrate-Lag) domain-containing protein that serves as a ligand for Notch receptors (NOTCH1-4). Key functions include:
JAG1-mediated Notch signaling is altered in Alzheimer's disease:
JAG1-Notch signaling modulators are being investigated for:
The study of Jag1 — Jagged 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.