Acsl4 Gene Acyl Coa Synthetase Long Chain Family Member 4 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| ACSL4 | |
|---|---|
| Gene Symbol | ACSL4 |
| Full Name | Acyl-CoA Synthetase Long Chain Family Member 4 |
| Chromosomal Location | Xq22.3 |
| NCBI Gene ID | 2072 |
| OMIM | 300402 |
| Ensembl ID | ENSG00000068366 |
| UniProt ID | O60488 |
| Protein | ACSL4 (Long-chain acyl-CoA synthetase 4) |
| Associated Diseases | Amyotrophic Lateral Sclerosis (ALS), Parkinson's Disease, Alzheimer's Disease, X-linked intellectual disability, Ferroptosis |
ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) encodes a member of the acyl-CoA synthetase family that catalyzes the conversion of long-chain fatty acids to acyl-CoA esters. ACSL4 is particularly important for ferroptosis sensitivity as it preferentially activates arachidonic acid and adrenic acid, which are substrates for lipid peroxidation during ferroptotic cell death.
ACSL4 catalyzes the following reaction:
What distinguishes ACSL4 from other ACSL family members:
ACSL4 is expressed in various neural cell types:
ACSL4 is a key determinant of ferroptosis sensitivity:
| Compound | Mechanism | Stage | Notes |
|---|---|---|---|
| Rosiglitazone | PPARγ agonist, indirect | Approved (diabetes) | Off-target ACSL4 |
| Triacsin C | Direct ACSL inhibitor | Research | Not selective |
| Thiazolidinediones | Indirect inhibition | Approved | Pioglitazone |
The study of Acsl4 Gene Acyl Coa Synthetase Long Chain Family Member 4 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.