Dctn3 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Gene Symbol: DCTN3
Full Name: Dynactin Subunit 3
Chromosomal Location: 9p13.3
NCBI Gene ID: 11259
OMIM: 609454
Ensembl ID: ENSG00000121957
UniProt ID: O75948
Associated Diseases: Neurological disorders
DCTN3 (Dynactin Subunit 3, also known as p24) is a subunit of the dynactin complex. While less studied than DCTN1, it contributes to the structural integrity and function of the dynactin complex in intracellular transport. The dynactin complex is essential for dynein-mediated retrograde axonal transport, and defects in this system are implicated in various neurodegenerative diseases.
DCTN3 (p24) is a subunit of the dynactin complex. While less studied than DCTN1, it contributes to the structural integrity and function of the dynactin complex in intracellular transport.
The dynactin complex is essential for dynein-mediated retrograde axonal transport. Defects cause:
DCTN3 is expressed in various tissues, with highest expression in brain and neuronal tissues.
The study of Dctn3 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.