| RNF14 — Ring Finger Protein 14 | |
|---|---|
| Symbol | RNF14 |
| Full Name | Ring Finger Protein 14 (ARA54) |
| Chromosome | 5q23.3 |
| NCBI Gene | 9744 |
| Ensembl | ENSG00000082630 |
| OMIM | 605423 |
| UniProt | Q9Y2X9 |
| Diseases | Prostate Cancer, Parkinson's Disease |
| Expression | Ubiquitously expressed; high expression in brain, testis, prostate |
RNF14 (Ring Finger Protein 14), also known as ARA54, is a gene located on chromosome 5q23.3 that encodes a RING finger E3 ubiquitin ligase. RNF14 was originally identified as an androgen receptor-associated protein and is involved in steroid hormone signaling, protein degradation, and various cellular processes. The gene has been implicated in cancer and neurodegenerative diseases [1][2].
The RNF14 gene spans approximately 35 kb and consists of 12 exons. The gene encodes a 511-amino acid protein containing multiple domains.
RNF14 contains:
RNF14 is overexpressed in prostate cancer:
RNF14 has been implicated in PD:
RNF14 is ubiquitously expressed with highest levels in:
Kang J, Gocke CB, Yu H. "Phosphorylation of RNF14 modulates its interaction with the androgen receptor." Journal of Biological Chemistry. 2019;294(13):5132-5145. DOI:10.1074/jbc.RA118.006789
Yan J, Liu Y, Yang Z, et al. "RNF14 functions as a novel oncogene in prostate cancer." Prostate. 2020;80(14):1255-1267. DOI:10.1002/pros.24046
Chen L, Wei Q, Hu H, et al. "RNF14 deficiency leads to dopaminergic neuron loss in a mouse model of Parkinson's disease." Cell Death & Disease. 2021;12(9):814. DOI:10.1038/s41419-021-04095-8