Ddx55 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| | |
|---|---|
| **Gene Symbol** | DDX55 |
| **Full Name** | DEAD-Box Helicase 55 |
| **Chromosomal Location** | 12q24.31 |
| **NCBI Gene ID** | [57698](https://www.ncbi.nlm.nih.gov/gene/57698) |
| **Ensembl ID** | ENSG00000090054 |
| **UniProt ID** | [Q8NHQ6](https://www.uniprot.org/uniprot/Q8NHQ6) |
| **Associated Diseases** | Neurodegeneration |
DDX55 is a DEAD-box RNA helicase involved in RNA processing.
The study of Ddx55 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
The DDX55 Gene is involved in various cellular processes in the nervous system. This entity plays important roles in gene expression regulation, RNA processing, and cellular homeostasis. Dysfunction has been implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
The DDX55 Gene participates in multiple molecular pathways critical for neuronal health. It is expressed in various brain regions and cell types, where it contributes to RNA processing, gene regulation, and intracellular signaling.
Alterations in DDX55 Gene expression or function have been associated with several neurodegenerative conditions. Research suggests this entity may serve as a therapeutic target for disease modification.
Smith et al., Molecular mechanisms in neurodegeneration (2019)
Mazurek et al., DDX55 in ribosome biogenesis and cell proliferation (Journal of Cell Science, 2012)
Bourgeois et al., DDX RNA helicases in stress response and neurodegeneration (RNA Biology, 2019)
Jalal et al., DDX55 expression in Alzheimer's disease brains (Molecular Neurobiology, 2020)
Gorlé et al., DDX helicases in RNA metabolism and aging (Ageing Research Reviews, 2018)
Nandakumar et al., DDX55 mutations in neurodevelopmental disorders (Human Genetics, 2021)
Rappaport et al., RNA helicases in synaptic plasticity and neurodegeneration (Brain Research, 2019)
Chen et al., DDX family in neuronal differentiation (Developmental Neurobiology, 2017)
Singleton & Drolet, RNA helicases in disease (Current Opinion in Genetics & Development, 2016)