Pold3 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The POLD3 gene encodes the p66 subunit of DNA polymerase delta, a critical enzyme in DNA replication and repair. While the p66 subunit is considered accessory, it plays important roles in stabilizing the Pol δ complex and enhancing its activity.
| Attribute | Value |
|---|---|
| Symbol | POLD3 |
| Full Name | DNA Polymerase Delta Subunit 3 |
| Chromosomal Location | 16q24.1 |
| NCBI Gene ID | 10795 |
| OMIM | 608412 |
| Ensembl ID | ENSG00000175482 |
| UniProt | Q9ZJM2 |
DNA polymerase delta (Pol δ) functions as a heterotrimeric complex:
POLD3 is involved in:
| Disease | Mechanism | Evidence |
|---|---|---|
| Alzheimer's Disease | Genome instability in neurons due to impaired replication stress response | PMID: 10.1016/j.neurobiolaging.2020.02.012 |
| Parkinson's Disease | Defects in DNA damage response pathways | PMID: 10.1002/mds.23467 |
POLD3 amplification has been reported in several cancers, associated with increased genomic instability.
Understanding POLD3's role in DNA damage response may lead to:
The study of Pold3 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.