Ifnar2 — Interferon Alpha Receptor 2 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Ifnar2 — Interferon Alpha Receptor 2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Interferon Alpha Receptor 2 | |
|---|---|
| Gene Symbol | IFNAR2 |
| Full Name | Interferon Alpha and Beta Receptor Subunit 2 |
| Chromosome | 21q22.1 |
| NCBI Gene ID | 3455 |
| OMIM | 206550 |
| Ensembl ID | ENSG00000159197 |
| UniProt ID | P48551 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, Systemic Lupus Erythematosus |
IFNAR2 encodes the interferon alpha receptor 2, the signal-transducing component of the type I interferon receptor. While IFNAR1 is primarily a binding subunit, IFNAR2 contains the intracellular domain necessary for JAK-STAT signaling. The receptor binds IFN-α, IFN-β, IFN-ω, and IFN-κ. IFNAR2 exists in both membrane-bound and soluble forms, with the soluble form acting as a natural antagonist. In the CNS, IFNAR2 mediates type I interferon effects on neurons and glia.
Expressed in most cell types including microglia, macrophages, neurons, and astrocytes. Alternative splicing generates soluble receptor isoforms.
| Disease | Variants | Inheritance | Mechanism |
|---|---|---|---|
| Alzheimer's Disease | Q64R | Risk factor | Chronic neuroinflammation |
| Parkinson's Disease | L144P | Risk factor | Altered interferon response |
| Multiple Sclerosis | F426S | Protective | Reduced signaling |
| SLE | Variants | Risk factor | Autoimmune dysfunction |
Ifnar2 — Interferon Alpha Receptor 2 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Ifnar2 — Interferon Alpha Receptor 2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.