Rps27 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Full Name | Ribosomal Protein S27 |
|---|---|
| Chromosomal Location | 2p16.3 |
| NCBI Gene ID | 6192 |
| OMIM | 603685 |
| Ensembl ID | ENSG00000177951 |
| UniProt ID | P62981 |
| Associated Diseases | Cancer |
RPS27 (Ribosomal Protein S27) is a component of the 40S ribosomal subunit and plays essential roles in protein synthesis, cell proliferation, and regulation of cell cycle pathways. As a ribosomal protein, RPS27 contributes to the structural and functional integrity of the ribosome, the molecular machine responsible for translating mRNA into proteins. Beyond its canonical role in translation, RPS27 has been implicated in extra-ribosomal functions including p53 activation, DNA damage response, and regulation of MDM2-mediated p53 degradation.
RPS27 is a component of the 40S ribosomal subunit. It is involved in protein synthesis and has been implicated in cell proliferation. RPS27 also has roles in p53 activation and cell cycle regulation.
RPS27 is ubiquitously expressed with high expression in proliferating cells.
The study of Rps27 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Ribosomal protein S27-like (RPS27L): structure, function and disease associations (2023)
RPS27 regulates p53 stability and translational reprogramming in cancer (2022)
The role of ribosomal proteins in cell proliferation and cell cycle control (2020)
RPS27 overexpression in human cancers: molecular mechanisms and therapeutic potential (2016)