TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily Member 1B), also known as TNFR2 or p75, is a member of the TNF receptor superfamily that primarily mediates pro-inflammatory and cell survival signals. Unlike TNFR1, TNFR2 lacks a death domain and predominantly activates NF-κB and MAPK pathways.
TNFR2 is a type I transmembrane receptor that binds both TNF-α and lymphotoxin-α. It is expressed predominantly in immune cells but also in neurons and glia, where it plays important roles in neuroinflammation and neuroprotection.
| TNF Receptor Superfamily Member 1B | |
|---|---|
| Gene Symbol | TNFRSF1B |
| Full Name | TNF Receptor Superfamily Member 1B |
| Chromosome | 1p36.22 |
| NCBI Gene ID | 7133 |
| OMIM | 191191 |
| Ensembl ID | ENSG00000022840 |
| UniProt ID | P20333 |
TNFR2 predominantly mediates pro-inflammatory signaling:
NF-κB pathway (primary):
MAPK pathways:
cAMP pathway:
TNFR2 has complex roles in AD:
In PD, TNFR2 contributes to:
TNFR2 is implicated in motor neuron disease:
TNFR2 plays important roles:
TNFR2 is a therapeutic target:
| Agent | Mechanism | Status | Disease |
|---|---|---|---|
| TNFR2 agonists | Enhance signaling | Research | Neuroprotection |
| TNFR2 antagonists | Block signaling | Research | MS |
| Small molecules | Modulate activity | Preclinical | Autoimmunity |
| Disease | Role | Evidence |
|---|---|---|
| Alzheimer's Disease | Mixed effects | TNFR2 in AD brain |
| Parkinson's Disease | Neuroprotection | TNFR2 agonists protective |
| ALS | Immune modulation | Altered expression |
| MS | Demyelination | TNFR2 in lesions |
TNFR2 is expressed in the nervous system: