Kcne4 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
KCNE4 modulates potassium channel activity. It is expressed in the heart and brain. The functional roles are still being characterized.
KCNE4 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 4) is a gene located on chromosome 2q36 that plays an important role in neurodegenerative disease. Mutations in KCNE4 are associated with Cardiac Disorders. The gene is catalogued as NCBI Gene ID 23704 and OMIM 607334.
The KCNE4 gene encodes a protein involved in key neuronal functions. It is expressed in Heart, Brain.
Expression data is available from the Allen Human Brain Atlas.
KCNE4 mutations are linked to the following conditions:
Cardiac Disorders
The study of Kcne4 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Potassium channels in neurons: Hille B. Ionic Channels of Excitable Membranes. 3rd ed. Sinauer Associates; 2001.
- KCNN channels (SK/IK): Stocker M. Nat Rev Neurosci. 2004;5(10):758-770. PMID:15378036
- KCa channels in neurodegeneration: Shah NH, et al. Nat Rev Neurosci. 2018;19(9):485-498. PMID:30046008
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