Ndufa10 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Ndufa10 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
.infobox-gene
!! colspan="2" style="background:#f8f9fa; text-align:center; font-weight:bold" | NDUFA10 - NADH:Ubiquinone Oxidoreductase Subunit A10
|-
! Chromosomal Location
| 2q37.3 |
|---|
! NCBI Gene ID
! OMIM
! Ensembl ID
! UniProt
! Associated Diseases
| Mitochondrial Complex I Deficiency |
|---|
NDUFA10 encodes a protein that is a structural component of the NADH dehydrogenase (Complex I). It is one of the accessory subunits that contribute to the overall architecture of the complex.
Mitochondrial Complex I Deficiency
Ubiquitously expressed with highest levels in heart, brain, and skeletal muscle. In brain, particularly enriched in dopaminergic neurons of substantia nigra.
Ndufa10 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Ndufa10 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1]: Sazanov LA. A giant molecular proton pump: structure and mechanism of respiratory complex I. Nat Rev Mol Cell Biol. 2015;16(6):375-388. PMID:25991374
[2]: Fiedorczuk K, et al. Atomic structure of the entire mammalian mitochondrial complex I. Nature. 2016;538(7625):299-302. PMID:27505352
[3]: Galkin A, et al. Identification of the mitochondrial NDUFAF2 as the complex I assembly factor. Cell. 2008;133(1):125-135. PMID:18342227
[4]: Lazarou M, et al. Novel mitochondrial complex I assembly factors. Methods Enzymol. 2009;457:85-105. PMID:19490921
[5]: Koopman WJ, et al. Mitochondrial complex I deficiency and neurological disease. J Clin Invest. 2015;125(3):919-931. PMID:25664952
[6]: Guerrero-Castillo S, et al. The assembly pathway of mitochondrial respiratory chain complex I. Nat Cell Biol. 2017;19(3):254-261. PMID:28218918
[7]: Antonicka H, et al. Mutations in COX10 result in a defect in mitochondrial heme A biosynthesis and cause complex IV deficiency. Am J Hum Genet. 2003;73(1):174-187. PMID:12707853
[8]: Janssen RJ, et al. Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease. Brain. 2009;132(Pt 4):833-842. PMID:19293253