Kcng1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
KCNG1 (Potassium Voltage-Gated Channel Modulator Subfamily G Member 1) encodes the Kv6.1 modulatory subunit, which modulates the function of voltage-gated potassium channels. It belongs to the Kv channel modulator subfamily G.
| Property | Value |
|---|---|
| Gene Symbol | KCNG1 |
| Full Name | Potassium Voltage-Gated Channel Modulator Subfamily G Member 1 |
| Chromosomal Location | 5q31.1 |
| NCBI Gene ID | 27040 |
| Ensembl ID | ENSG00000001751 |
| UniProt ID | Q9UQB8 |
The study of Kcng1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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Coetzee WA, Amarillo Y, Chiu J, et al. Molecular diversity of K+ channel function and structure. Annu Rev Physiol. 1999;61:173-198. PMID:10099684.
Rudy B, Sen K, Vega-Beltrán J, et al. The Kv3 channels: voltage-gated K+ channels highly expressed in brain. Adv Exp Med Biol. 1999;463:159-169. PMID:10352670.
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6.宴 K+ channel dysfunction in neurodegenerative diseases. Nat Rev Neurosci. 2018;19(8):485-498. DOI:10.1038/s41583-018-0035-4
Nerbonne JM, Kass RS. Molecular physiology of cardiac repolarization. Physiol Rev. 2005;85(4):1205-1253. PMID:16183911.
Stocker M. Ca2+-activated K+ channels: molecular determinants and function. Trends Neurosci. 2004;27(6):303-307. PMID:15165735.