Pik3R1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Pik3R1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1) encodes the p85α regulatory subunit of phosphoinositide 3-kinase (PI3K), a critical signaling molecule that regulates cell survival, growth, and metabolism[1][2].
| Attribute | Value |
|---|---|
| Gene Symbol | PIK3R1 |
| Full Name | Phosphoinositide-3-Kinase Regulatory Subunit 1 |
| Chromosomal Location | 5q13.1 |
| Protein Class | PI3K regulatory subunit (SH2 domain-containing) |
| Aliases | p85α, PI3K-p85, GRB1 |
PIK3R1 encodes the p85α regulatory subunit, which plays essential roles in PI3K/Akt signaling[1:1]:
The p85α protein contains:
The PI3K/Akt pathway is critically involved in Alzheimer's disease pathogenesis[3][4]:
In Parkinson's disease, PI3K/Akt signaling is crucial for[5][6]:
PI3K is a key mediator of brain insulin signaling[7]:
| Interactor | Interaction Type | Functional Significance |
|---|---|---|
| PIK3CA (p110α) | Catalytic subunit | PI3K enzymatic activity |
| PTEN | Negative regulator | Dephosphorylates PIP3 |
| IRS1/2 | Substrate | Insulin signaling adaptor |
| GRB2 | Adapter protein | Growth factor signaling |
| Akt1/PKB | Downstream kinase | Cell survival effector |
PIK3R1 is expressed throughout the brain:
PI3K modulators are being investigated for neurodegenerative diseases[8]:
Pik3R1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Pik3R1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Cantley LC. (2002). The phosphoinositide 3-kinase pathway. Science. DOI:10.1126/science.296.5573.1655 ↩︎ ↩︎
Fruman DA, et al. (2017). The PI3K pathway in human disease. Cell. DOI:10.1016/j.cell.2017.06.020 ↩︎
Talbot K, et al. (2012). Brain insulin resistance in Alzheimer's disease. J Alzheimers Dis. PMID:22710913 ↩︎
Liu Y, et al. (2019). PI3K/Akt signaling in Alzheimer's disease. Mol Neurobiol. PMID:30635866 ↩︎
Xing X, et al. (2020). PI3K/Akt in Parkinson's disease. Prog Neuropsychopharmacol Biol Psychiatry. PMID:31759012 ↩︎
Kim KS, et al. (2021). Neuroprotective role of PI3K signaling in dopaminergic neurons. Exp Neurol. PMID:33497654 ↩︎
Arnold SE, et al. (2018). Brain insulin resistance in AD. Nat Rev Neurol. PMID:29545551 ↩︎
Degroot A, et al. (2023). Targeting PI3K for neurodegeneration therapy. Pharmacol Rev. DOI:10.1124/pharmrev.122.000654 ↩︎