| Attribute | Value | [1]
|----------|-------|
| Symbol | RPL24 |
| Name | Ribosomal Protein L24 |
| Chromosome | 3p21.31 |
| NCBI Gene ID | 6149 |
| UniProt ID | P83775 |
RPL24 encodes Ribosomal Protein L24, a highly conserved protein component of the large (60S) ribosomal subunit. RPL24 plays a critical role in ribosome structure and function, contributing to:
Beyond translation, RPL24 has been implicated in:
RPL24 is among the ribosomal proteins showing altered expression in Alzheimer's disease (AD) brain tissue. Studies have documented decreased RPL24 levels in AD hippocampus, contributing to the well-characterized translational deficits in AD neurons [8]. This reduction in ribosomal protein expression affects:
In Parkinson's disease (PD), RPL24 expression is altered in dopaminergic neurons of the substantia nigra. Research has demonstrated that ribosomal protein dysregulation contributes to neuronal vulnerability in PD [9]. RPL24 variants have been investigated for their potential role in PD susceptibility [10].
Paradoxically, while RPL24 is often upregulated in various cancers (contributing to enhanced protein synthesis in proliferating cells), its dysfunction has been linked to neurodegenerative processes [11].
RPL24 plays a central role in the cellular stress response:
Stress-Induced Translation Shutdown: Under cellular stress, RPL24 helps coordinate translational repression [12]
Stress Granule Formation: RPL24 can be recruited to stress granules, affecting mRNA triage [13]
Integrated Stress Response (ISR): RPL24 participates in the ISR pathway, which is activated in neurodegenerative diseases [14]
RPL24 expression in the brain shows regional specificity:
This widespread expression explains its broad involvement in various neurodegenerative conditions [15].
Targeting RPL24 and ribosomal function offers therapeutic potential:
Ribosomal proteins and translation fidelity - RNA Biol (2013). 2013. ↩︎
RPL24 and cell cycle regulation - Cell Cycle (2012). 2012. ↩︎
Ribosomal proteins in stress response - Nat Rev Mol Cell Biol (2014). 2014. ↩︎
Translational dysregulation in AD brain - J Neurosci (2003). 2003. ↩︎
Gene expression in PD substantia nigra - Brain (2004). 2004. ↩︎
RPL24 variants and PD risk - Park Relat Disord (2016). 2016. ↩︎
RPL24 in cancer and neurodegeneration - Cell Death Differ (2015). 2015. ↩︎
Stress-induced translation control - Cold Spring Harb Perspect Biol (2013). 2013. ↩︎
Stress granules and neurodegeneration - Nat Rev Neurol (2020). 2020. ↩︎
Integrated stress response in neurodegeneration - Nat Rev Neurosci (2019). 2019. ↩︎
Brain region-specific ribosomal protein expression - Brain Res (2011). 2011. ↩︎
ISR inhibitors for neurodegeneration - Neurobiol Dis (2020). 2020. ↩︎
Translational modulators in AD therapy - Pharmacol Rev (2019). 2019. ↩︎
Neuroprotective strategies targeting translation - Trends Pharmacol Sci (2021). 2021. ↩︎