| FOXO4 — Forkhead Box O4 | |
|---|---|
| Symbol | FOXO4 |
| Full Name | Forkhead Box O4 |
| Chromosome | Xq13.1 |
| NCBI Gene | 8941 |
| Ensembl | ENSG00000124780 |
| OMIM | 300434 |
| UniProt | P98177 |
| Diseases | Parkinson's Disease, Alzheimer's Disease, Amyotrophic Lateral Sclerosis |
| Expression | Ubiquitous; high expression in brain, muscle, and liver |
FOXO4 (Forkhead Box O4) is a transcription factor belonging to the FOXO subfamily of Forkhead box proteins. It regulates genes involved in stress resistance, metabolism, cell cycle arrest, and apoptosis[1]. FOXO4 has been implicated in neurodegenerative diseases where it plays complex roles in neuronal survival and death.
FOXO4 is one of four mammalian FOXO transcription factors (FOXO1, FOXO3, FOXO4, FOXO6). It contains a conserved forkhead DNA-binding domain and transcriptional activation domain. FOXO4 activity is regulated by post-translational modifications including phosphorylation, acetylation, and ubiquitination.
Key upstream regulators:
In PD:
In AD:
The study of Foxo4 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.