== Function ==
NRCAM (Neuronal Cell Adhesion Molecule) is a member of the L1 family of cell adhesion molecules (L1-CAMs). It is a transmembrane glycoprotein with six Ig-like domains and five fibronectin type III repeats in its extracellular region. NRCAM mediates homophilic (NRCAM-NRCAM) and heterophilic (NRCAM-ankyrin-G) interactions that are essential for neuronal migration, axon guidance, and synapse formation. [1]
NRCAM plays critical roles in: [2]
== Disease Associations == [3]
NRCAM variants have been associated with: [4]
== Expression == [5]
NRCAM shows high expression in: [6]
== Key Publications == [7]
== References == [8]
NRCAM (Neuronal Cell Adhesion Molecule) encodes a neuronal adhesion molecule of the L1 family that mediates cell-cell adhesion and axon guidance. NRCAM plays important roles in nervous system development, including neurite outgrowth, myelination, and synapse formation. NRCAM is expressed in the developing brain and continues to be expressed in adult neurons. Genetic variants in NRCAM have been associated with autism spectrum disorder and multiple sclerosis. [9]
Sakurai et al. NRCAM in synapse formation (2011). 2011. ↩︎
Maness et al. NCAM and L1 in neuronal development and regeneration (2004). 2004. ↩︎
Sakurai et al. NCAM regulates synaptic plasticity and learning (2011). 2011. ↩︎
Pollerberg et al. NCAM in axon guidance and synaptogenesis (2013). 2013. ↩︎
Hansen et al. NRCAM in neuropsychiatric disorders (2014). 2014. ↩︎
Matsumoto et al. NRCAM polymorphisms and schizophrenia risk (2008). 2008. ↩︎
Wegner et al. NCAM-mediated neural development (2010). 2010. ↩︎
Koshi et al. NCAM in Alzheimer's disease pathology (2012). 2012. ↩︎
Bhattacharya et al. NRCAM and autism spectrum disorders (2015). 2015. ↩︎