PILRB (Paired Immunoglobulin-like Type 2 Receptor Beta) encodes a membrane protein involved in immune cell signaling. While primarily studied in natural killer cells and macrophages, PILRB has emerging roles in neuroinflammation and neurodegenerative disease pathogenesis[1].
| Property | Value |
|---|---|
| Gene Symbol | PILRB |
| Gene Name | Paired Immunoglobulin-like Type 2 Receptor Beta |
| Chromosomal Location | 7q22.1 |
| NCBI Gene ID | 29998 |
| UniProt ID | Q9Y5U4 |
| Gene Type | Protein Coding |
PILRB contains several key structural features:
The presence of ITIM motifs suggests an inhibitory function in immune cell signaling[2].
PILRB performs important immune regulatory functions:
PILRB is expressed primarily in immune cells:
In the brain, PILRB is primarily expressed on microglial cells, the resident immune cells of the central nervous system.
PILRB contributes to neurodegenerative diseases through neuroinflammatory mechanisms:
PILRB influences brain immune cell function:
The receptor mediates crosstalk between peripheral immune system and brain:
PILRB may contribute to AD pathogenesis through:
In PD:
| Disease | Evidence Level | Mechanism |
|---|---|---|
| Alzheimer's Disease | Moderate | Neuroinflammation, microglial function |
| Parkinson's Disease | Moderate | Microglial activation |
| Multiple Sclerosis | Moderate | Autoimmunity, demyelination |
| Viral infections | Confirmed | Immune cell regulation |
PILRB interacts with several signaling proteins:
| Protein | Interaction Type | Functional Consequence |
|---|---|---|
| ITIM effectors | Phosphatases | Negative signaling |
| NK cell receptors | Regulation | Cell activation control |
| Cytoskeletal proteins | Intracellular | Signal transduction |
PILRB offers several therapeutic opportunities:
Satoh T et al. PILR beta is a cellular receptor for HSV-1 entry. 2006. ↩︎
Kogelman K et al. PILRB in immune regulation and viral susceptibility. 2017. ↩︎