Oprd1 — Delta Opioid Receptor is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Delta-Opioid Receptor (DOR) is a The delta-opioid receptor is involved in pain modulation, emotional processing, and motor control. It has been implicated in epilepsy, depression, and has neuroprotective properties relevant to neurodegenerative diseases.
| Symbol | OPRD1 |
|---|---|
| Full Name | Delta-Opioid Receptor (DOR) |
| Chromosomal Location | 1p36.12 |
| NCBI Gene ID | 4981 |
| OMIM | 165070 |
| Ensembl ID | ENSG00000116381 |
| UniProt | P41143 |
The OPRD1 gene encodes a G protein-coupled receptor that The delta-opioid receptor is involved in pain modulation, emotional processing, and motor control. It has been implicated in epilepsy, depression, and has neuroprotective properties relevant to neurodegenerative diseases.
This receptor couples to G proteins to activate downstream signaling cascades:
| Disease | Role | Evidence |
|---|---|---|
| Parkinson's disease | Receptor alterations affect dopaminergic signaling | GWAS, postmortem studies |
| Schizophrenia | Altered receptor expression and signaling | Genetic association, PET studies |
| Movement disorders | Receptor polymorphisms affect motor control | Clinical studies |
This receptor is expressed in various brain regions:
Expression data available from Allen Brain Atlas.
The study of Oprd1 — Delta Opioid Receptor has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.