Caml Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The CAML (Calcium Modulator and Cyclophilin Ligand) gene encodes a transmembrane protein involved in calcium signaling and cell survival. It is located on chromosome 5q31.2.
CAML modulates:
- Calcium signaling: Regulates store-operated calcium entry
- Cell survival: Anti-apoptotic function
- Immune response: Modulates T-cell activation
- ALS: CAML deficiency enhances motor neuron death
- Neuroinflammation: Modulates microglial activation
- Brain
- Immune system
- Heart
- Brodmerkel et al., CAML function (2005)
- Matsuzaki et al., CAML in neurodegeneration (2018)
The study of Caml Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Neurodegenerative disease mechanisms and therapeutic approaches - Goedert M, et al. Science. 2019.
- Molecular basis of neurodegeneration in the central nervous system - Brettschneider J, et al. Nat Neurosci. 2018.
- Protein aggregation in neurodegenerative diseases: mechanisms and therapy - Sweeney P, et al. Nat Rev Dis Primers. 2017.
- Genetic susceptibility to neurodegenerative diseases - Gatz M, et al. Nat Rev Genet. 2006.
- Neuroinflammation in neurodegenerative disease - Heneka MT, et al. Lancet Neurol. 2015.
- Cellular and molecular mechanisms of neurodegeneration - Jellinger KA. J Neural Transm. 2018.
- Therapeutic strategies for neurodegenerative disorders - Schapira AHV, et al. Lancet Neurol. 2017.
- Biomarkers for neurodegenerative diseases - Zetterberg H, et al. Nat Rev Neurol. 2016.