TGFBR1 (Transforming Growth Factor Beta Receptor 1) is a critical component of TGF-beta signaling in the nervous system. This page provides detailed information about its structure, function, and role in neurodegenerative diseases.
TGFBR1 (Transforming Growth Factor Beta Receptor 1) encodes the transmembrane serine/threonine kinase receptor that mediates TGF-beta signaling in the central nervous system[1][2]. As the primary type I receptor for TGF-beta ligands, TGFBR1 plays essential roles in regulating neuroinflammation, neuronal survival, synaptic plasticity, and glial cell function[3].
| Attribute | Value |
|---|---|
| Official Symbol | TGFBR1 |
| Official Full Name | Transforming Growth Factor Beta Receptor 1 |
| Chromosomal Location | 9q22.33 |
| NCBI Gene ID | 7046 |
| OMIM | 191181 |
| Ensembl ID | ENSG00000106799 |
| UniProt ID | P36897 |
TGFBR1 is a transmembrane receptor kinase consisting of:
Upon ligand binding to the type II receptor (TGFBR2), TGFBR1 is recruited and transphosphorylated at key serine/threonine residues, activating its kinase domain[4].
TGFBR1 is expressed throughout the brain:
The study of Tgfbr1 — Transforming Growth Factor Beta Receptor 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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