Fyn — Fyn Proto Oncogene, Src Family Tyrosine Kinase is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Symbol | FYN |
| Full Name | FYN Proto-Oncogene, Src Family Tyrosine Kinase |
| Chromosomal Location | 6q21 |
| NCBI Gene ID | 2534 |
| OMIM | 137025 |
| Ensembl ID | ENSG00000110881 |
| UniProt ID | P39687 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Schizophrenia, Multiple Sclerosis |
FYN (FYN Proto-Oncogene, Src Family Tyrosine Kinase) is a member of the Src family of non-receptor tyrosine kinases (SFKs). It is involved in neuronal signaling, immune cell activation, and synaptic plasticity. FYN plays important roles in learning and memory, NMDA receptor function, and myelin formation. It is implicated in Alzheimer's disease, schizophrenia, and multiple sclerosis.
FYN encodes a member of the Src family of non-receptor tyrosine kinases (SFKs). These kinases are critical signaling molecules that regulate numerous cellular processes including cell growth, differentiation, survival, migration, and synaptic function.
Src family kinases consist of an N-terminal myristoylation site for membrane association, a unique domain, SH3 and SH2 domains for protein-protein interactions, and a catalytic tyrosine kinase domain. They are activated by various receptors including growth factor receptors, integrins, and immune receptors.
In the nervous system, FYN plays important roles in synaptic plasticity, NMDA receptor signaling, and neuronal survival. It is involved in the phosphorylation of various substrates including NMDA receptor subunits, PSD-95, and tau.
FYN is expressed throughout the brain with high expression in the cortex, hippocampus, and cerebellum. Expression is regulated during development and by neuronal activity.
Src family kinase inhibitors are in development for neurodegenerative diseases:
The study of Fyn — Fyn Proto Oncogene, Src Family Tyrosine Kinase has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.