Cd36 — Cd36 Molecule is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| CD36 — CD36 Molecule | |
|---|---|
| Symbol | CD36 |
| Full Name | CD36 Molecule |
| Chromosome | 7q21.11 |
| NCBI Gene | 948 |
| Ensembl | ENSG00000135218 |
| OMIM | 173510 |
| UniProt | P16671 |
| Diseases | Alzheimer's Disease, Atherosclerosis, Diabetes, Stroke |
| Expression | Macrophages, Microglia, Platelets, Adipocytes, Heart |
CD36 is a gene located on chromosome 7q21.11 that encodes a class B scavenger receptor with multiple ligands. CD36 is a transmembrane glycoprotein expressed on various cell types including macrophages, microglia, platelets, and adipocytes, where it participates in fatty acid transport, oxidized LDL uptake, and immune responses.
CD36 has diverse functions:
In the brain, CD36 on microglia mediates responses to amyloid-beta and contributes to neuroinflammatory processes.
Alzheimer's Disease: CD36 is a major receptor for Aβ on microglia. It mediates microglial activation, cytokine production, and Aβ clearance. CD36 polymorphisms may influence AD risk and progression.
Stroke: CD36 contributes to inflammatory damage after ischemia. CD36 deficiency is protective in stroke models.
ALS: CD36 expression is altered in ALS models.
The study of Cd36 — Cd36 Molecule has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.