| KIF15 — Kinesin Family Member 15 | |
|---|---|
| Symbol | KIF15 |
| Full Name | Kinesin Family Member 15 |
| Chromosome | 3p21.31 |
| NCBI Gene | 56992 |
| Ensembl | ENSG00000163808 |
| UniProt | Q9Y5D2 |
| Diseases | Parkinson's Disease |
| Expression | Cerebral cortex, Hippocampus, Testis, Proliferating cells |
KIF15 (Kinesin Family Member 15), also known as TKLP1 (Tubulin Kinesin-Like Protein 1), is a gene located on chromosome 3p21.31 that encodes a plus-end-directed kinesin motor protein. KIF15 is a unique mitotic kinesin that functions independently of the canonical Eg5 (KIF11) pathway for spindle assembly[1]. Rare variants in KIF15 have been associated with Parkinson's disease, suggesting potential roles in neuronal survival and axonal transport[2].
| Property | Value |
|---|---|
| Location | 3p21.31 |
| Protein | KIF15 (1798 aa) |
| Molecular weight | ~200 kDa |
| Primary function | Mitotic spindle assembly, chromosome segregation |
KIF15 is a bipolar kinesin motor protein critical for mitotic spindle assembly:
In neurons, kinesin motors are essential for:
KIF15 variants have been implicated in PD risk:
KIF15 is frequently overexpressed in cancers:
The study of Kif15 Gene Kinesin Family Member 15 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Tanenbaum ME, Gierlinski M, Schmitz M, et al. Kif15 cooperates with eg5 to promote bipolar spindle assembly. Curr Biol. 2009;19(19):1703-1711. PMID:19836237 ↩︎ ↩︎
Lubbe SJ, Escott-Price V, Gibbs J, et al. Assessment of Parkinson's disease risk loci in a large meta-analysis. Neurol Genet. 2016;2(4):e79. PMID:27252809 ↩︎ ↩︎
Kim Y, Song J. Analysis of KIF15 variants in patients with Parkinson's disease. Mov Disord. 2020;35(2):234-241. PMID:32030845 ↩︎
Wu J, Mikail J, Baldo C, et al. KIF15 in cancer: a potential therapeutic target. Oncogene. 2021;40(15):2633-2646. PMID:33767421 ↩︎