KDM2A (Lysine Demethylase 2A), also known as FBXL11 or JHDM1A, is a histone demethylase that specifically removes methyl groups from histone H3 at lysine 36 (H3K36). This enzyme regulates transcription, DNA repair, and cellular differentiation.
| Property |
Value |
| Gene Symbol |
KDM2A |
| Gene Name |
Lysine Demethylase 2A |
| Aliases |
FBXL11, JHDM1A, NEDMCL |
| Chromosomal Location |
11q13.1 |
| NCBI Gene ID |
22992 |
| OMIM |
605469 |
| UniProt |
Q9Y2K2 |
| Ensembl |
ENSG00000107140 |
KDM2A is a Jumonji C domain-containing demethylase:
Demethylates:
- H3K36me2 (primary)
- H3K36me1
- H3K4me3 (weaker)
¶ Domains
- JmjC domain: Catalytic
- CXXC domain: DNA-binding
- F-box: Protein interactions
KDM2A regulates gene expression:
- Represses transcription through H3K36 demethylation
- Modifies chromatin states
- Affects RNA polymerase II function
Involved in DNA damage response:
- Nucleotide excision repair
- Regulates repair factor recruitment
Controls cell proliferation:
- Regulates cell cycle progression
- Affects senescence
KDM2A dysregulation in:
- Prostate cancer
- Breast cancer
- Lung cancer
- Renal cell carcinoma
Potential roles in:
- Neurodevelopment
- Neurodegeneration
KDM2A is a H3K36-specific demethylase with roles in transcription, DNA repair, and cell cycle regulation.
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