Tial1 — Tia1 Cytotoxic Granule Associated Rna Binding Protein Like 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| TIAL1 | |
|---|---|
| Gene Symbol | TIAL1 |
| Full Name | TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1 |
| Chromosome | 10q11.23 |
| NCBI Gene ID | 7073 |
| OMIM | 604713 |
| Ensembl ID | ENSG00000173113 |
| UniProt ID | Q9YKf3 |
| Associated Diseases | Amyotrophic Lateral Sclerosis |
TIAL1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1) is a gene located on chromosome 10q11.23 that encodes a RNA-binding protein involved in stress granule formation and regulation of apoptosis. It is closely related to TIA1 and is implicated in amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases.
TIAL1 encodes a member of the TIA1-like family of RNA-binding proteins with high homology to TIA1. It contains three RNA recognition motifs (RRMs) and functions in stress granule assembly and translational regulation. TIAL1 can compensate for TIA1 loss and has overlapping but distinct functions in RNA metabolism.
In neurons, TIAL1 participates in stress response pathways, translational control, and may play roles in synaptic function and neuronal survival under stress conditions.
Expressed in brain tissue with expression patterns overlapping with TIA1. TIAL1 localizes to stress granules during cellular stress.
| Disease | Variants | Inheritance | Mechanism |
|---|---|---|---|
| Amyotrophic Lateral Sclerosis | — | Risk factor | Dysregulated stress granule dynamics |
The study of Tial1 — Tia1 Cytotoxic Granule Associated Rna Binding Protein Like 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.