Tardbp — Tar Dna Binding Protein 43 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Tardbp — Tar Dna Binding Protein 43 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Property | Value |
|---|---|
| Gene Symbol | TARDBP |
| Full Name | TDP-43 (TAR DNA-binding protein) |
| Chromosomal Location | 1p36.22 |
| NCBI Gene ID | 23435 |
| OMIM ID | 605520 |
| Ensembl ID | ENSG00000120948 |
| UniProt ID | Q13148 |
| Encoded Protein | TDP-43 (TAR DNA-binding protein) |
| Associated Diseases | Amyotrophic lateral sclerosis, Frontotemporal dementia, Alzheimer's disease |
TARDBP encodes TDP-43, a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays critical roles in RNA metabolism. TDP-43 is a DNA/RNA-binding protein that regulates gene expression at multiple levels.
Key normal physiological functions include:
TARDBP mutations are a major cause of familial and sporadic ALS:
TARDBP is linked to FTD subtypes:
TDP-43 pathology is observed in approximately 30-50% of AD cases:
TARDBP is ubiquitously expressed with highest levels in neurons:
The Allen Brain Atlas shows high TARDBP expression in:
Tardbp — Tar Dna Binding Protein 43 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Tardbp — Tar Dna Binding Protein 43 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.