Ctf18 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Property | Value |
|---|---|
| Gene Symbol | CTF18 |
| Full Name | Chromosome Transmission Fidelity 18 |
| Chromosomal Location | 7q22.1 |
| NCBI Gene ID | 63922 |
| OMIM ID | 607196 |
| Ensembl ID | ENSG00000132905 |
| UniProt ID | Q8IY92 |
| Encoded Protein | Chromosome transmission fidelity factor 18 |
| Associated Diseases | Chromosome instability, neurodegeneration |
CTF18 is a gene involved in various cellular processes. The encoded protein plays important roles in metabolism, cellular signaling, and disease pathogenesis.
CTF18 encodes a subunit of the Ctf18-RFC complex, which loads proliferating cell nuclear antigen (PCNA) onto DNA for replication and repair.
Key functions include:
CTF18 mutations cause chromosome instability syndromes with:
CTF18 deficiency may lead to neurodegeneration through:
CTF18 is expressed in:
The study of Ctf18 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.