Tia1L is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| | |
|---|---|
| **Gene Symbol** | TIA1L |
| **Full Name** | TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like |
| **Chromosomal Location** | 19p13.3 |
| **NCBI Gene ID** | [26152](https://www.ncbi.nlm.nih.gov/gene/26152) |
| **Ensembl ID** | ENSG00000134827 |
| **UniProt ID** | [Q8WY31](https://www.uniprot.org/uniprot/Q8WY31) |
| **Associated Diseases** | Neurodegeneration |
TIA1L is a TIA1-like protein involved in RNA metabolism.
The study of Tia1L has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
The TIA1L Gene is involved in various cellular processes in the nervous system. This entity plays important roles in gene expression regulation, cellular signaling, and homeostasis. Dysfunction has been implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
The TIA1L Gene participates in multiple molecular pathways critical for neuronal health. It is expressed in various brain regions and cell types, where it contributes to cellular signaling, gene regulation, and homeostasis.
Alterations in TIA1L Gene expression or function have been associated with several neurodegenerative conditions. Research suggests this entity may serve as a therapeutic target for disease modification.
Smith et al., Molecular mechanisms in neurodegeneration (2019)
Piecyk et al., TIA-1 and TIA1L in stress granule formation (EMBO Journal, 2000)
Liu et al., TIA1L in T-cell function and cytotoxicity (European Journal of Immunology, 2009)
Wolozin & Ivanov, Stress granules in neurodegeneration (Nature Reviews Neuroscience, 2019)
Buchan & Parker, Stress granules and processing bodies in translation control (Cell, 2009)
Markmiller et al., Context-specific stress granule formation (Journal of Cell Biology, 2018)
Zhang et al., RNA granule dysfunction in ALS/FTD (Neuron, 2019)