Dctn4 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Gene Symbol: DCTN4
Full Name: Dynactin Subunit 4
Chromosomal Location: 14q11.2
NCBI Gene ID: 11318
OMIM: 614732
Ensembl ID: ENSG00000131470
UniProt ID: Q9UBW9
Associated Diseases: Cystic Fibrosis (modifier), Neurological disorders
DCTN4 (Dynactin Subunit 4) is a subunit of the dynactin complex involved in dynein-dynactin-mediated retrograde transport. It may play a role in neuronal development and function. The dynactin complex is essential for dynein-mediated retrograde axonal transport, and defects in this system are implicated in various neurodegenerative diseases.
DCTN4 is a subunit of the dynactin complex involved in dynein-dynactin-mediated retrograde transport. It may play a role in neuronal development and function.
The dynactin complex is essential for dynein-mediated retrograde axonal transport. Defects cause:
DCTN4 is expressed in various tissues, with expression in brain and neuronal tissues.
The study of Dctn4 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.