Isg15 — Interferon Stimulated Gene 15 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| ISG15 | |
|---|---|
| Gene Symbol | ISG15 |
| Full Name | Interferon-Stimulated Gene 15 |
| Chromosome | 1p36.33 |
| NCBI Gene ID | 9636 |
| OMIM | 607117 |
| Ensembl ID | ENSG00000187608 |
| UniProt ID | P51959 |
| Associated Diseases | Parkinson's Disease, Amyotrophic Lateral Sclerosis, Alzheimer's Disease |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
ISG15 encodes a ubiquitin-like protein that is induced by type I interferons (IFN-α/β) and plays a critical role in the innate immune response. ISG15 functions through two main mechanisms:
In the nervous system, ISG15 is involved in:
ISG15 is expressed in:
Expression is typically low under basal conditions but is rapidly induced by viral infections, type I interferons, and inflammatory stimuli.
ISG15 has been implicated in Parkinson's disease pathogenesis:
The study of Isg15 — Interferon Stimulated Gene 15 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.