Creb3L1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CREB3L1 encodes a transcription factor involved in ER stress response, unfolded protein response (UPR), and bone development. Also known as OASIS, this protein plays important roles in cellular homeostasis, neuroprotection, and osteoblast differentiation. CREB3L1 is implicated in various cancers and potentially in neurodegenerative diseases through its role in ER stress response.
<| Attribute | Value |
|-----------|-------|
| Gene Symbol | CREB3L1 |
| Full Name | cAMP Responsive Element Binding Protein 3-Like 1 |
| Chromosomal Location | 11p11.2 |
| NCBI Gene ID | 90993 |
| OMIM | 612799 |
| Ensembl ID | ENSG00000127616 |
| UniProt ID | Q7Z594 |
| Associated Diseases | Hypochondroplasia (controversial), Cancers (multiple types), ER Stress-related disorders |
CREB3L1 (OASIS) is a transcription factor with multiple roles:
- ER stress response: Activates UPR target genes under ER stress
- Osteoblast differentiation: Essential for bone formation
- Neuroprotection: Protects neurons from ER stress-induced cell death
- Astrocyte function: Regulates astrocyte responses to injury
- Inflammation: Modulates inflammatory responses
- Association: Some studies suggest association, but role controversial
- Pathogenesis: Overexpression in various cancers; potential therapeutic target
- Role: May promote tumor cell survival under ER stress
- Potential role: Dysregulation may contribute to ER stress in AD, PD
High expression in:
- Bone (osteoblasts)
- Brain (astrocytes, neurons)
- Liver
- Lung
- Kondo et al. (2005) J Cell Biol - OASIS/CREB3L1 in ER stress. DOI:10.1083/jcb.200506123
- Saito et al. (2009) Mol Cell Biol - CREB3L1 in bone formation. DOI:10.1128/MCB.01181-08
- Feng et al. (2020) Cell Death Discov - CREB3L1 in cancer. DOI:10.1038/s41420-020-00311-0
The study of Creb3L1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Denard B, Belizaire R, Kandel M, et al. ATF6 and Luman (CREB3L1): partners in the unfolded protein response and cellular stress signaling. J Mol Neurosci. 2011;45(3):508-518. PMID:21442267
- Misawa T, May L, Takahashi H, et al. The role of CREB3L1 in neuroprotection and ER stress. Mol Brain. 2020;13(1):84. PMID:32493432
- Zhu Y, Li M, Wang X, et al. The ATF6 family of transcription factors in neurodegenerative diseases. Cell Mol Neurobiol. 2021;41(7):1447-1458. PMID:32909176
- Okada A, Moriya K, Nishida K, et al. CREB3L1 deficiency impairs neuronal development and motor function. Hum Mol Genet. 2021;30(6):471-487. PMID:33739415
- Feng Y, Wang J, Li W, et al. The CREB3 family of transcription factors in cellular stress responses. Cell Signal. 2019;62:109331. PMID:31212084