| BAG1 | |
|---|---|
| Full Name | BAG1 Molecular Chaperone Regulator |
| Chromosomal Location | 9q33.3 |
| NCBI Gene ID | 573 |
| OMIM | 602677 |
| UniProt ID | O95817 |
| Ensembl ID | ENSG00000102172 |
| Category | Molecular Chaperone |
The {symbol} gene encodes a co-chaperone that interacts with Hsp70 family proteins through its BAG domain. BAG1 acts as a nucleotide exchange factor for Hsc70, stimulating ATP hydrolysis and substrate release. It links the Hsp70 chaperone system to various cellular processes including apoptosis, transcription, and protein degradation. BAG1 can sequester Bcl-2 and inhibit apoptosis.
BAG1 encodes a co-chaperone that interacts with Hsp70 family proteins through its BAG domain. Acts as a nucleotide exchange factor for Hsc70, stimulating ATP hydrolysis and substrate release. Links chaperone system to apoptosis and transcription.
| Disease | Role in Disease |
|---|---|
| Alzheimer's Disease | Influences tau pathology and neuronal survival |
| Parkinson's Disease | Protects against dopaminergic neuron death |
| Amyotrophic Lateral Sclerosis | BAG1 levels correlate with motor neuron survival |
BAG1 is widely expressed in the brain with high levels in cortex, hippocampus, and cerebellum. Multiple isoforms are generated through alternative splicing. Expression is elevated in response to cellular stress and during brain development.