Kcnn1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
KCNN1 (SK1) encodes a small-conductance calcium-activated potassium channel. SK channels regulate neuronal excitability and contribute to afterhyperpolarization. They are expressed throughout the brain and are targets for potential therapeutic interventions in epilepsy.
KCNN1 (Potassium Calcium-Activated Channel Subfamily N Member 1) is a gene located on chromosome 1p22 that plays an important role in neurodegenerative disease. Mutations in KCNN1 are associated with Epilepsy, Neuronal Excitability. The gene is catalogued as NCBI Gene ID 3776 and OMIM 609921.
The KCNN1 gene encodes a protein involved in key neuronal functions. It is expressed in Brain, Hippocampus, Cortex.
Expression data is available from the Allen Human Brain Atlas.
KCNN1 mutations are linked to the following conditions:
Epilepsy, Neuronal Excitability
The study of Kcnn1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.