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Ribosomal Protein S27 Like is a ribosomal protein involved in protein synthesis and ribosome function. Ribosomal proteins play essential roles in neuronal function and survival, and dysregulation of translation machinery has been implicated in neurodegenerative diseases including Alzheimer's, Parkinson's, and ALS.
Ribosomal Protein S27 Like (gene symbol: RPS27L) is a member of the ribosomal protein family. Ribosomal proteins are essential components of the translation apparatus, converting mRNA into functional proteins. In neurons, where protein synthesis is crucial for synaptic plasticity and neuronal survival, ribosomal dysfunction can contribute to neurodegeneration.
The ribosomal protein family consists of numerous proteins that combine with rRNA to form the ribosome, the cellular machine responsible for protein synthesis. Mutations or dysregulation of ribosomal proteins can lead to:
Research has shown that ribosomal proteins can have extraribosomal functions, including roles in DNA repair, cell cycle regulation, and apoptosis. In neurodegeneration, ribosomal dysfunction contributes to:
See also: Ribosomal Proteins Family, Translation, Neurodegeneration.
RPS27L is a ribosomal protein that plays a role in protein synthesis. It also functions as a tumor suppressor and is involved in p53-mediated apoptosis. Dysregulation has been implicated in cancer and may affect neuronal survival.
Expressed in most tissues with high expression in brain.
Mutations in RPS27L are associated with Cancer; Neurodegeneration. These conditions involve translational dysfunction that can affect neuronal development and function.
Xiong X et al. (2011) Cell Cycle 10(10):1564-1571.
De Keersmaecker K et al. (2015) Nat Rev Cancer 15(10):599-612.