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| Symbol | HRH4 |
| Full Name | Histamine Receptor H4 |
| Chromosome | 18p11.21 |
| NCBI Gene | 59340 |
| OMIM | 609792 |
| Ensembl | ENSG00000134489 |
| UniProt | Q9Y5N2 |
| Associated Diseases | Inflammation, allergy |
HRH4 (Cholinergic Receptor Nicotinic Alpha Subunit) is a gene encoding a protein that plays important roles in neuronal signaling and has been implicated in neurodegenerative diseases including Alzheimer's and Parkinson's disease.
The HRH4 gene encodes a critical subunit of nicotinic acetylcholine receptors (nAChRs), which are ligand-gated ion channels important for fast synaptic transmission in the central nervous system. These receptors are widely expressed in the brain and play roles in cognitive function, attention, and motor control.
Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels composed of alpha and beta subunits. The HRH4 subunit contributes to receptor heterogeneity and influences receptor trafficking, conductance properties, and pharmacological sensitivity. Research has shown that variations in HRH4 are associated with nicotine dependence, and dysregulation of these receptors has been observed in neurodegenerative conditions.
HRH4 encodes the histamine H4 receptor, primarily expressed in immune cells and bone marrow. It plays roles in inflammatory responses and may have implications for neuroinflammation in neurodegenerative diseases.
HRH4 encodes the H4 histamine receptor. Involved in immune function and cell migration.
Expressed in immune cells and brain.