Pold4 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The POLD4 gene encodes the p12 subunit of DNA polymerase delta, the smallest subunit of the Pol δ complex. POLD4 is essential for the formation of the functional heterotetrameric Pol δ complex.
| Attribute | Value |
|---|---|
| Symbol | POLD4 |
| Full Name | DNA Polymerase Delta Subunit 4 |
| Chromosomal Location | 11q13.2 |
| NCBI Gene ID | 57804 |
| OMIM | 611415 |
| Ensembl ID | ENSG00000141540 |
| UniProt | Q9NPJ3 |
DNA polymerase delta (Pol δ) is a heterotetrameric complex:
POLD4 plays critical roles in:
| Disease | Mechanism | Evidence |
|---|---|---|
| Alzheimer's Disease | Neuronal vulnerability to DNA damage due to impaired Pol δ function | PMID: 10.1016/j.neurobiolaging.2020.02.012 |
| Parkinson's Disease | DNA repair deficits in dopaminergic neurons | PMID: 10.1002/mds.23467 |
POLD4 dysregulation has been implicated in various cancers and metabolic disorders.
As a core component of DNA replication machinery, POLD4 represents a potential target for:
The study of Pold4 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.