| SUMO1 — Small Ubiquitin-Like Modifier 1 | |
|---|---|
| Symbol | SUMO1 |
| Full Name | Small Ubiquitin-Like Modifier 1 |
| Chromosome | 2q33 |
| NCBI Gene | 7341 |
| Ensembl | ENSG00000116030 |
| OMIM | 601561 |
| UniProt | P63165 |
| Diseases | Neurodegeneration, Cancer, Diabetes |
| Expression | Ubiquitous - High in brain, heart, liver |
Sumo1 — Small Ubiquitin Like Modifier 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
SUMO1 (Small Ubiquitin-Like Modifier 1) is a gene located on chromosome 2q33 that encodes the SUMO1 protein, a member of the SUMO family of ubiquitin-like proteins. SUMOylation is a post-translational modification process that involves the covalent attachment of SUMO proteins to target proteins, regulating their localization, stability, activity, and protein-protein interactions.1
The gene is catalogued as NCBI Gene ID 7341.
SUMO1 encodes a small ubiquitin-like protein (~101 amino acids) that can be covalently attached to lysine residues in target proteins through an enzymatic cascade involving E1, E2, and E3 enzymes.
SUMOylation regulates:
SUMO1 is ubiquitously expressed with high levels in:
SUMOylation is critically involved in neurodegenerative diseases:
The study of Sumo1 — Small Ubiquitin Like Modifier 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Page auto-generated from NeuroWiki gene database.