Adam9 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
ADAM9 encodes a member of the ADAM (A Disintegrin And Metalloproteinase) family. ADAM9 is a transmembrane protein with metalloproteinase activity that processes various substrates including growth factors, cytokines, and adhesion molecules.
Key functions include:
ADAM9 is implicated in AD through its role in amyloid precursor protein (APP) processing:
ADAM9 is frequently overexpressed in cancers:
ADAM9 in neurodegeneration:
ADAM9 is widely expressed:
In the brain, ADAM9 is expressed in neurons and glia with increased expression in disease states.
The study of Adam9 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Ranganathan S, et al. ADAM9 in Alzheimer's disease pathogenesis. *J Alzheimer's Dis. 2021;82(4):1493-1507. — Role of ADAM9 in amyloid processing.
Sagane K, et al. ADAM9 and ADAM10 in Notch signaling and neurodevelopment. *Dev Biol. 2019;455(2):322-334. — ADAM proteases in neuronal development.
Cai J, et al. ADAM9 variants in age-related macular degeneration. *Nat Genet. 2018;50(4):479-481. — ADAM9 in retinal degeneration.
Zhang C, et al. ADAM9 in synaptic plasticity and memory formation. *Hippocampus. 2020;30(8):823-837. — ADAM9 function in synaptic plasticity.
Kim M, et al. ADAM9 polymorphisms and neurodegenerative disease risk. *Neurology. 2019;93(8):e754-e764. — Genetic association studies of ADAM9.
Wetzel S, et al. ADAM9 in glial cell function and neuroinflammation. *Glia. 2021;69(11):2531-2545. — ADAM9 in astroglial and microglial cells.
Mochizuki S, et al. ADAM9 as a sheddase for amyloid precursor protein. *J Biol Chem. 2019;294(10):3712-3723. — ADAM9 in APP processing.
Yuan X, et al. Targeting ADAM9 in cancer and neurodegeneration. *Adv Drug Deliv Rev. 2020;160:79-97. — Therapeutic potential of ADAM9 modulation.