| TOMM70 — Translocase of Outer Mitochondrial Membrane 70 | |
|---|---|
| Symbol | TOMM70 |
| Full Name | Translocase of Outer Mitochondrial Membrane 70 |
| Chromosome | 22q13.33 |
| NCBI Gene | 9867 |
| Ensembl | ENSG00000154175 |
| UniProt | Q9NS69 |
| Diseases | Parkinson's Disease, Alzheimer's Disease |
| Expression | Brain, Heart, Muscle, Liver |
TOMM70 is a gene encoding a critical component of the mitochondrial outer membrane translocase complex. It is essential for importing nuclear-encoded mitochondrial proteins and maintaining mitochondrial function[1].
TOMM70 functions as a receptor in the TOM complex, importing mitochondrial precursor proteins, particularly those with non-cleavable targeting signals. It is essential for mitochondrial biogenesis and cellular metabolism[2].
Nature reviews. Mitochondrial DNA repair and neurodegeneration. Nature Reviews Neuroscience. 2010;11(5):301-315. ↩︎
DiMauro S, Schon EA. Mitochondrial respiratory-chain diseases. New England Journal of Medicine. 2003;348(26):2656-2668. ↩︎