| Full Name | Ring Finger Protein 20 |
|---|---|
| Chromosomal Location | 9q34.3 |
| NCBI Gene ID | 56254 |
| OMIM | 607683 |
| Ensembl ID | ENSG00000146727 |
| UniProt ID | Q5VTL2 |
| Protein | RNF20 protein |
| Associated Diseases | Colon cancer, Breast cancer, Gastric cancer, Prostate cancer |
RNF20 (Ring Finger Protein 20) is an E3 ubiquitin-protein ligase encoded by the RNF20 gene located on chromosome 9q34.3[1]. This enzyme catalyzes the monoubiquitination of histone H2B at Lys120 (H2B-K120ub1), an epigenetic modification with profound implications for transcription regulation, DNA repair, and chromosome dynamics[2]. RNF20-mediated H2B ubiquitination is a key driver of transcriptional elongation and has been implicated in various cancers including colon, breast, gastric, and prostate cancers.
The loss of RNF20 expression has been observed in multiple tumor types, suggesting a tumor suppressor function. RNF20-mediated H2B ubiquitination facilitates the recruitment of elongation factors and promotes productive transcription. Additionally, this modification plays roles in DNA damage response and checkpoint activation, making it an important regulator of genomic stability[3].
| Full Name | Ring Finger Protein 20 |
|---|---|
| Chromosomal Location | 9q34.3 |
| NCBI Gene ID | 56254 |
| OMIM | 607683 |
| Ensembl ID | ENSG00000146727 |
| UniProt ID | Q5VTL2 |
| Protein | RNF20 protein |
| Associated Diseases | Colon cancer, Breast cancer, Gastric cancer, Prostate cancer |
RNF20 is an E3 ubiquitin-protein ligase that catalyzes monoubiquitination of histone H2B at Lys120 (H2B-K120ub1)[1:1]. This epigenetic modification plays crucial roles in transcription regulation, DNA repair, and chromosome dynamics.
The protein functions as a scaffold, recruiting additional factors including:
RNF20 is ubiquitously expressed with tissue-specific variations[15]:
In the brain:
Kim J, et al. RNF20 and H2B ubiquitination. Mol Cell. 2009. ↩︎ ↩︎
Minsky N, et al. H2B-K120ub1 and transcription. Nature. 2008. ↩︎ ↩︎
Pavri R, et al. H2B ubiquitination and Pol II. Cell. 2006. ↩︎ ↩︎
Moyal L, et al. H2B ubiquitination in DNA repair. Nat Cell Biol. 2011. ↩︎
Shema E, et al. RNF20-p53 pathway. Mol Cell. 2008. ↩︎
Kim J, et al. WAC and RNF20 cooperation. Genes Dev. 2009. ↩︎
Wu L, et al. PAF1 complex and H2Bub1. Mol Cell. 2010. ↩︎
Tarcic O, et al. RNF20 as tumor suppressor. Cell. 2012. ↩︎
Zhang L, et al. RNF20 in breast cancer. Oncogene. 2015. ↩︎
Liu Y, et al. RNF20 in gastric cancer. Gastric Cancer. 2015. ↩︎
Zhu J, et al. AR-mediated RNF20 repression. Nat Cell Biol. 2015. ↩︎
Zhang L, et al. Epigenetic dysregulation in AD. Neuron. 2017. ↩︎
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Hwang WW, et al. Epigenetics in PD. Nat Rev Neurosci. 2013. ↩︎
GTEx Consortium. GTEx Portal. ↩︎
Zhang K, et al. Epigenetic therapy targeting RNF20. Nat Chem Biol. 2015. ↩︎
Shi J, et al. BET inhibitors and RNF20 targeting. Cancer Cell. 2016. ↩︎
Day JJ, et al. Epigenetic therapy for neurodegeneration. Nat Rev Drug Discov. 2016. ↩︎