| Gene Symbol | NCF4 |
|---|---|
| Full Name | Neutrophil Cytosolic Factor 4 (p40phox) |
| Chromosomal Location | 22q13.1 |
| NCBI Gene ID | 3074 |
| OMIM | 604467 |
| Ensembl ID | ENSG00000100129 |
| UniProt ID | Q9UHI5 |
| Associated Diseases | Chronic Granulomatous Disease, Parkinson's Disease, Inflammatory Diseases |
Neutrophil Cytosolic Factor 4 (NCF4), also known as p40phox, is a regulatory subunit of the NADPH oxidase (NOX2) complex that plays a critical role in generating reactive oxygen species (ROS) in phagocytic cells.[1] While primarily studied in the immune system, NCF4 is also expressed in microglia, the resident immune cells of the brain, where it contributes to neuroinflammatory processes.[2]
In neurodegenerative diseases, NCF4 polymorphisms have been associated with altered disease risk, and its activity in microglia contributes to chronic neuroinflammation—a hallmark of both Alzheimer's and Parkinson's diseases.[3]
NCF4 encodes the p40phox subunit, a component of the NADPH oxidase (NOX2) complex. It plays a regulatory role in assembling and activating the oxidase complex in phagocytic cells.