| HSPA10 — Heat Shock Protein Family A (Hsp70) Member 10 | |
|---|---|
| Symbol | HSPA10 |
| Full Name | Heat Shock Protein Family A (Hsp70) Member 10 |
| Chromosome | 12q13.12 |
| NCBI Gene | 3336 |
| OMIM | 610175 |
| Ensembl | ENSG00000113013 |
| UniProt | P54652 |
| Diseases | [Lung Cancer](/diseases/lung-cancer), [Breast Cancer](/diseases/breast-cancer), [Autoimmune Disorders](/diseases/autoimmune), [Chronic Inflammation](/diseases/chronic-inflammation) |
| Expression | Ubiquitous, highest in lymphoid tissues, testes, placenta |
HSPA10, also known as Hsp70L1 (Heat Shock Protein 70-Like 1) or Hsp70-5, is a member of the Hsp70 family of molecular chaperones. While initially characterized as a testis-specific Hsp70 protein, HSPA10 has emerged as a multifunctional protein involved in immune regulation, protein folding, and cellular stress responses.
HSPA10 encodes a 641-amino acid protein belonging to the Hsp70 family. Unlike canonical Hsp70s, HSPA10 lacks the C-terminal substrate-binding domain variability and is primarily localized to the cytosol and nucleus. HSPA10 is constitutively expressed at low levels and is upregulated in response to various cellular stresses.
HSPA10 functions as a molecular chaperone, assisting in protein folding, refolding, and assembly of protein complexes. Like other Hsp70 family members, HSPA10 utilizes ATP-dependent substrate binding and release cycles to facilitate protein homeostasis.
HSPA10 plays significant roles in immune function:
HSPA10 is frequently overexpressed in various cancers and is associated with:
HSPA10 overexpression is observed in lung cancer, breast cancer, colorectal cancer, and other malignancies. HSPA10 promotes tumor progression through:
HSPA10 may play complex roles in autoimmunity:
HSPA10 expression is modulated in chronic inflammatory conditions, and the protein may serve both pro-inflammatory and anti-inflammatory roles depending on context.
HSPA10 exhibits widespread expression with highest levels in:
Lower expression is detected in most other tissues including brain, heart, lung, liver, and kidney. Expression is induced by heat shock and other cellular stresses.
HSPA10 represents a therapeutic target for: