PPP2R1B encodes the beta isoform of the regulatory subunit A of protein phosphatase 2A (PP2A). PP2A is a major serine/threonine phosphatase critical for tau dephosphorylation, and its dysfunction is implicated in Alzheimer's disease.
PPP2R1B (Protein Phosphatase 2 Regulatory Subunit A Beta) encodes the beta isoform of the PP2A subunit A. Together with PPP2R1A (alpha isoform), it forms the structural scaffold for the PP2A holoenzyme, which is essential for dephosphorylating tau and other neuronal proteins.
| Property | Value |
|---|---|
| Gene Symbol | PPP2R1B |
| Full Name | Protein Phosphatase 2 Regulatory Subunit A Beta |
| Chromosomal Location | 11q23.2 |
| NCBI Gene ID | 5519 |
| OMIM ID | 616982 |
| Ensembl ID | ENSG00000137713 |
| UniProt ID | P30101 |
| Encoded Protein | PP2A subunit A beta (PR65-beta) |
| Associated Diseases | Alzheimer's disease, tauopathies, cancer |
PPP2R1B provides the scaffold for PP2A complex assembly.
Key normal physiological functions include:
The study of Ppp2R1B Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.