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| Symbol | EFNA1 |
| Full Name | Ephrin A1 |
| Chromosome | 1q21.3 |
| NCBI Gene | 1942 |
| OMIM | 191055 |
| Ensembl | ENSG00000139842 |
| UniProt | P20827 |
| Associated Diseases | Alzheimer's disease, cancer |
EFNA1 (Ephrin A1) is a GPI-anchored ligand for EPHA receptors that mediates cell-cell communication and regulates synaptic plasticity. As an ephrin family member, EFNA1 plays crucial roles in neural development, synaptic function, and cellular signaling. Altered EFNA1 expression has been implicated in neurodegenerative diseases, particularly Alzheimer's disease, as well as in various cancers.
EFNA1 is a GPI-anchored ligand for EPHA receptors. It mediates cell-cell communication and regulates synaptic plasticity. EFNA1 expression is altered in AD brain.
Expressed in most tissues, including brain.