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| Symbol | EPHA2 |
| Full Name | Eph Receptor A2 |
| Chromosome | 1p34.3 |
| NCBI Gene | 1969 |
| OMIM | 176945 |
| Ensembl | ENSG00000142627 |
| UniProt | P21802 |
| Associated Diseases | Alzheimer's disease, cancer |
EPHA2 (Eph Receptor A2) is a member of the Eph receptor tyrosine kinase family that plays crucial roles in neural development, synaptic plasticity, and cellular communication. As a receptor tyrosine kinase that binds ephrin-A ligands, EPHA2 regulates dendritic spine morphology, synaptic function, and neural circuit formation. Dysregulated EPHA2 signaling has been implicated in neurodegenerative diseases, particularly Alzheimer's disease, as well as in various cancers.
EPHA2 is a receptor tyrosine kinase that binds ephrin-A ligands. It regulates synaptic plasticity, dendritic spine morphology, and neural circuit formation. Dysregulated EPHA2 signaling is implicated in neurodegeneration.
High expression in hippocampus, cortex, and retina.