| SYN3 — Synapsin III | |
|---|---|
| Symbol | SYN3 |
| Full Name | Synapsin III |
| Chromosome | 22q12.3 |
| NCBI Gene | 8864 |
| Ensembl | ENSG00000185608 |
| OMIM | 600731 |
| UniProt | O75907 |
| Protein Class | Synapsin Family |
| Expression | Cerebral cortex, Hippocampus, Synaptic terminals, Retina |
Syn3 — Synapsin Iii is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
SYN3 (Synapsin III) is a gene located on chromosome 22q12.3 encoding Synapsin III, a neuronal phosphoprotein associated with synaptic vesicles[1]. Synapsin III is the least characterized member of the synapsin family, which also includes SYN1 and SYN2. It plays critical roles in synaptogenesis, synaptic vesicle trafficking, and neurotransmitter release[2]. The gene is catalogued as NCBI Gene ID 8864.
| Property | Value |
|---|---|
| Gene Symbol | SYN3 |
| Full Name | Synapsin III |
| Chromosomal Location | 22q12.3 |
| NCBI Gene ID | 8864 |
| Ensembl ID | ENSG00000185608 |
| OMIM ID | 600731 |
| UniProt ID | O75907 |
| Protein Length | 580 amino acids |
| Molecular Weight | ~63 kDa |
Synapsin III contains several functional domains:
The protein is associated with the cytoplasmic surface of synaptic vesicles[3].
Synapsin III is involved in:
In the brain, SYN3 is expressed in:
| Property | SYN1 | SYN2 | SYN3 |
|---|---|---|---|
| Chromosome | X | 3 | 22 |
| Isoforms | 3 | 2 | 1 |
| Brain expression | High | High | Moderate |
| Knockout phenotype | Seizures | Behavioral | Viable |
SYN3 has been implicated in Parkinson's disease:
SYN3 is associated with schizophrenia:
SYN3 interacts with:
The study of Syn3 — Synapsin Iii has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Hvalby O, et al. (2006). Synapsin-vertebrate synapsin III. Brain Res. 1085(1):76-84. PMID:16650406 ↩︎
Cesca F, et al. (2010). The synapsins: key actors of synapse function and plasticity. Prog Neurobiol. 91(4):313-348. PMID:20418147 ↩︎
Gitler D, et al. (2004). Molecular determinants of synapsin modulation of GABAergic signaling. J Neurophysiol. 92(5):2839-2848. PMID:15175368 ↩︎