Sust Sulfatase Modifying Factor 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Sulfatase Modifying Factor 1 | |
|---|---|
| Gene Symbol | SUST |
| Full Name | Sulfatase Modifying Factor 1 |
| Chromosome | 2q33.1 |
| NCBI Gene ID | 6299 |
| OMIM | 607059 |
| Ensembl ID | ENSG00000164053 |
| UniProt ID | O75079 |
| Associated Diseases | Multiple Sulfatase Deficiency |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
Sulfatase Modifying Factor 1 (SUMF1) is an enzyme that catalyzes the post-translational modification of cysteine to formylglycine in all sulfatases. This modification is essential for sulfatase catalytic activity[^1].
SUMF1 performs functions:
SUMF1 mutations cause multiple sulfatase deficiency:
SUMF1 is expressed in:
The study of Sust Sulfatase Modifying Factor 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.