Dync1Li2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
{{infobox .infobox-gene}}
| Property | Value |
|---|---|
| Gene Symbol | DYNC1LI2 |
| Full Name | Dynein Cytoplasmic 1 Light Intermediate Chain 2 |
| Chromosomal Location | 15q21.3 |
| NCBI Gene ID | 1786 |
| OMIM ID | 614777 |
| Ensembl ID | ENSG00000170840 |
| UniProt ID | Q8IWV1 |
| Associated Diseases | Neurodegeneration, Cancers |
This page provides comprehensive information about the DYNC1LI2 gene and its role in neurodegenerative diseases. The gene encodes a protein involved in various molecular pathways relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
DYNC1LI2 encodes the second light intermediate chain isoform of the cytoplasmic dynein-1 complex. Like its paralog DYNC1LI1, it serves as a regulatory subunit that modulates dynein function and cargo binding.
The dynein complex is essential for:
Dysregulation of dynein-mediated transport is implicated in:
Expressed in most tissues, with high expression in brain and testis.
The study of Dync1Li2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.