Nfat2 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Nfat2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
NFAT2 (Nuclear Factor of Activated T cells 2, also called NFATc1) is a transcription factor that plays critical roles in immune response, neural development, and synaptic plasticity. In the brain, NFAT2 regulates genes involved in neuroinflammation, memory formation, and neuronal survival.
| Property | Value |
|---|---|
| Gene Symbol | NFAT2 (NFATc1) |
| Full Name | Nuclear Factor of Activated T Cells 2 |
| Chromosomal Location | 18p11.22 |
| NCBI Gene ID | 7992 |
| OMIM | 600489 |
| Ensembl ID | ENSG00000106436 |
| UniProt | O95644 |
| Associated Diseases | Alzheimer's Disease, Multiple Sclerosis, Stroke |
NFAT2 has diverse functions in the immune and nervous systems:
NFAT2 is expressed in:
Title: NFAT proteins: key regulators of T-cell development and function
Authors: Macian F, et al.
Journal: Nature Reviews Immunology
Year: 2001
[DOI:10.1038/35000526](https://doi.org/10.1038/35000526)
Title: NFAT-regulated gene expression in the brain
Authors: Nguyen T, Di Giovanni S
Journal: Nature Reviews Neuroscience
Year: 2008
[DOI:10.1038/nrn2454](https://doi.org/10.1038/nrn2454)
Nfat2 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Nfat2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.